Factores predictivos del síndrome de retirada de abirateron / Predictive factors for abiraterone withdrawal syndrome

Introducción y objetivo: El síndrome de retirada de abiraterona (SRA) se caracteriza por un descenso transitorio de PSA tras la discontinuación del tratamiento con acetato de abiraterona (AA) en los pacientes diagnosticados de cáncer de próstata resistente a castración metastásico (CPRCm). El objetivo de nuestro estudio es identificar posibles factores predictivos al diagnóstico que puedan influir en el SRA. Materiales y métodos: Se realizó un estudio retrospectivo de los pacientes que recibieron tratamiento con AA en el Institut Català d'Oncologia - L'Hospitalet entre 2015 y 2017, obteniendo una muestra de 70 pacientes. Resultados: Presentaron SRA 11 pacientes. La edad media al diagnóstico fue 65,73 años y la edad media de presentación 74,18 años. El número de ciclo de tratamiento fue el noveno. La mediana de PSA al diagnóstico fue de 30,5ng/ml; la mediana de PSA en el SRA, 33,24 ng/ml; y la mediana de PSA antes de iniciar otro tratamiento, 15,78 ng/ml. La media de seguimiento tras SRA fue de 8,2 meses. Los factores predictivos del SRA serían PSA elevado (p = 0,002), ISUP ≥ 4 (p = 0,002) y estadio IV al diagnóstico (p < 0,001). El estadio T presenta un riesgo elevado, pero sin significación estadística. Se obtuvo una ABC ROC de 0,84, con un IC 95% entre 0,77 y 0,92 (p < 0,001). Conclusiones: La incidencia del SRA no es despreciable, describiendo respuestas prolongadas tras la retirada del AA, incluso la posibilidad de una mejoría en la supervivencia global. Estos resultados podrían suponer un cambio en el esquema de tratamiento del CPRCm

Introduction and objective: Abiraterone withdrawal syndrome (AWS) is characterized by a transient decrease in the PSA after abiraterone acetate (AA) treatment discontinuation in patients diagnosed with metastatic castration-resistant prostate cancer (mCRPC). The aim of our study is to identify the possible predictive factors of AWS at diagnosis. Materials and methods: We performed a retrospective study of 70 patients treated with AA at the Institut Català d'Oncologia - L'Hospitalet between 2015 and 2017. Results: Eleven patients presented AWS. The mean age at diagnosis was 65.73 years and the mean age of presentation was 74.18 years. Patients were in the ninth treatment cycle. The median PSA was: 30.5 ng/ml at diagnosis, 33.24 ng/ml in the AWS, and 15.78 ng/ml before starting another treatment. The median follow-up period after AWS was 8.2 months. The predictive factors of AWS would be: high PSA (p = 0.002), ISUP ≥ 4 (p = 0.002) and stage IV at diagnosis (p<0.001). Patients with a T stage present high risk, but without statistical significance. An AUC of 0.84 was obtained, with a 95% CI between 0.77 and 0.92 (p < 0.001). Conclusions: The incidence of AWS is not negligible, describing prolonged responses after AA withdrawal, including the possibility of increased overall survival. These results could entail new treatment schemes for mCRPC

Predictive factors for abiraterone withdrawal syndrome. / Factores predictivos del síndrome de retirada de abiraterona.

INTRODUCTION AND OBJECTIVE: Abiraterone withdrawal syndrome (AWS) is characterized by a transient decrease in the PSA after abiraterone acetate (AA) treatment discontinuation in patients diagnosed with metastatic castration-resistant prostate cancer (mCRPC). The aim of our study is to identify the possible predictive factors of AWS at diagnosis. MATERIALS AND METHODS: We performed a retrospective study of 70 patients treated with AA at the Institut Català d'Oncologia - L'Hospitalet between 2015 and 2017. RESULTS: 11 patients presented AWS. The mean age at diagnosis was 65.73 years and the mean age of presentation was 74.18 years. Patients were in the ninth treatment cycle. The median PSA was: 30.5ng/ml at diagnosis, 33.24ng/ml in the AWS, and 15.78ng/ml before starting another treatment. The median follow-up period after AWS was 8.2 months. The predictive factors of AWS would be: high PSA (p=.002), ISUP≥4 (p=.002) and stage IV at diagnosis (p<.001). Patients with a T stage present high risk, but without statistical significance. An AUC of 0.84 was obtained, with a 95% CI between 0.77 and 0.92 (p<.001). CONCLUSIONS: The incidence of AWS is not negligible, describing prolonged responses after AA withdrawal, including the possibility of increased overall survival. These results could entail new treatment schemes for mCRPC.

[Rectal cancer. The effect of the clinical stage and the degree of lymphatic invasion on local recurrence and survival. An analysis of 168 patients]. / Cáncer de recto. Influencia del estadio clínico y grado de invasión ganglionar en la recidiva local y en la supervivencia. Análisis de 168 pacientes.

INTRODUCTION: Surgery is the most important therapeutic means for treatment of rectal carcinoma. Nevertheless, from stage B2, relapse rates are high and it is therefore necessary to use supplemental treatments such as radiotherapy associated or not with chemotherapy OBJECTIVE: To assess the likelihood of being free of local, local and distant disease and overall and specific survival in function of clinical stage and degree of lymph node involvement among patients diagnosed with colo-rectal adenocarcinoma treated with radical surgery and radiotherapy associated or not with chemotherapy. MATERIALS AND METHODS: Since January 1990 up to December 1997, all patients with rectal adenocarcinoma treated with radical surgery and postoperative radiotherapy, with or without chemotherapy, were prospectively included in a database which was analyzed. RESULTS: The crude actuarial survival at five years was 61.1 +/- 9.2% and specific survival 64.2 +/- 9.2%. As for stages: B (84.1 +/- 10.1%) and C (49.9 +/- 3.3%) (p < 0.001). Likewise, for N0 84.1 +/- 10.1%, for N1 62.2 +/- 13.5% and for N2 13.7 +/- 22.3% (p < 0.001). The likelihood of being in complete remission for the overall patient population was 50.2 +/- 9.2%: B (67.5 +/- 13.5%) and C (37.9 +/- 11.9%) (p < 0.001). Likewise, for N0 67.5 +/- 13.5%, for N1 47.8 +/- 13.5%, and for N2 9.9 +/- 17% (p < 0.001). CONCLUSIONS: Given the poor results obtained in stages C, particularly stage N2 and also that a better local control is obtained with good tolerance when preoperative radiotherapy is administered, we believe that in order to improve the results it is necessary to initiate preoperative radiotherapy.

[Role of radiotherapy in the treatment of localized prostatic carcinoma]. / Papel de la radioterapia en el tratamiento del carcinoma prostático localizado.

OBJECTIVES: Radical treatment for prostate cancer aims at complete eradication of tumor. Over the last 30 years, a vast literature has been published on the available therapeutic approaches for loco-regionally confined prostate cancer. There is no consensus on the appropriate management of either early stage or locally advanced disease and treatment is still given on the basis of physician preconception, training and instinct. METHODS: The indications and results of postradical prostatectomy adjuvant pelvic radiation therapy and radical radiation therapy are reviewed. RESULTS: Following radical prostatectomy, extracapsular disease, carrying a significant risk of local recurrence, is found from 12-68% of the time depending on the clinical tumor stage. External beam radiotherapy is a reference for treatment standards for prostate cancer. CONCLUSIONS: External irradiation remains the unquestioned standard for the treatment of locally advanced disease. For early stage disease, patients have the option of selecting radical prostatectomy or radiotherapy.